Jurnal Ilmu Keperawatan dan Kebidanan
KORELASI KADAR INSULIN-LIKE GROWTH FACTOR I (IGF-I) SERUM MATERNAL DENGAN ANTROPOMETRI BAYI BARU LAHIR
Abstract
Pertumbuhan intrauterin yang tidak optimal dapat menyebabkan bayi lahir dengan berat badan, panjang badan dan lingkar kepala kecil. Keadaan ini dipengaruhi oleh berbagai faktor salah satunya Insulin-like Growth Factor I (IGF-I). Insulin-like Growth Factor I maternal berperan penting dalam transpor nutrisi dan ibu ke janin melalui plasenta. Kadar IGF-I maternal diduga berkorelasi positif dengan antropometri bayi baru lahir. Tujuan penelitian ini adalah untuk mengetahui korelasi kadar IGF-I maternal dengan antropometri bayi baru lahir. Disain penelitian adalah cross sectional,observasional terhadap 56 ibu melahirkan di RSUD Dr. Rasidin, RS Tk III Reksodiwiryo Padang bulan Juni sampai Agustus 2015 dengan teknik consecutive sampling. Kadar IGF-I diukur dengan menggunakan metode ELISA di Laboratorium Biomedik Universitas Andalas. Uji normalitas data dengan Kolmogorov-Smirnov, uji Spearman untuk korelasi IGF-I dengan berat badan, panjang badan dan lingkar kepala bayi baru lahir dan uji Mann-Whitney untuk menilai perbedaan kadar IGF-I. Hasil penelitian menunjukkan median kadar IGF-I maternal adalah 219,42 (203,46-267,18) ng/ml, berat badan badan 3100 (2100-4300) gram, panjang badan 48 (44-50) cm dan lingkar kepala 34 (31,5-37,5) cm. Terdapat korelasi positif yang lemah dan tidak signifikan antara IGF-I maternal dengan berat badan (r=0,206, p=0,128), dan terdapat korelasi positif yang sangat lemah dan tidak signifikan antara IGF-I maternal dengan panjang badan (r=0,186, p=0,170) dan lingkar kepala (r=0,160, p=0,238). Kesimpulan penelitian ini adalah terdapat korelasi positif yang tidak signifikan antara kadar IGF-I serum maternal dengan antropometri bayi baru lahir.
Full Text:
PDFReferences
Almatsier, S., Soetardjo, S., & Soekatri, M. (2011). Gizi Seimbang dalam Daur Kehidupan. Jakarta: PT Gramedia Pustaka Utama.
Asvold, B. O., Eskild, A., Jenum, P. A., & Vatten, L. J. (2011). Maternal concentration of insulin-like growth factor 1 and insulin-like growth factor binding protein during pregnancy and birthweight offspring. American Journal of Epidemiology , 1-7.
BKKBN. (2013). Profil Kependudukan dan Pembangunan di Indonesia Tahun 2013. Jakarta: Badan Kependudukan dan Keluarga Berencana Nasional
Brett, K., Ferraro, Z., Yockell-Lelievre, J., Gruslin, A., & Adamo, K. (2014). Maternal-fetal nutrient transport in pregnancy pathology: the role of the placenta. International Journal of Molecular Science , 16153-16185.
Chiesa, C., Osborn, J., Haass, C., Natale, F., Spinelli, M., Scapillati, E., et al. (2008). Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: is there a relationship with fetal growth and neonatal anthropometry. Clinical Chemistry , 350-358.
Forbes, K., & Westwood, M. (2008). The IGF Axis and Placental Function. Horm Res , 129-137.
Gatford, K. (2014). Circulating IGF1 and IGF2 and SNP genotypes in men and pregnant and non pregnant women. Endoctine Connection , 1-12.
Gluckman, P., & Pinal, C. (2003). Regulation of Fetal Growth by the Somatotrophic Axis. The Journal of Nutrition
Grissa, O., Yessoufo, A., Mrisak, I., Hichami, A., Amoussou-Guenou, D., Grissa, A., et al. (2010). Growth factor concentrations and their placental mRNA expression are modulated in gestational diabetes mellitus: possible interactions with macrosomia. BMC Pregnancy and Childbirth , 1-10.
Higgins, M., Russell, N., Crossey, P., Nyhan, K., Brazil, D., & Mcauliffe, F. (2012). Maternal and fetal placental growth hormone and IGF axis type 1 diabetic pregnancy. Plos One , 1-8.
Holmes, R. P., Holly, J., & Soothill, P. W. (2000). Maternal insulin-like growth factor binding protein-1, body mass index, and fetal growth. Arch Dis Child Fetal Neonatol , 113-117.
Jansson, N., Nisfelt, A., Gellerstedt, M., Wennergren, M., Rossander-Hulthen, L., Powell, T. L., et al. (2008). Maternal hormones linking maternal body mass index and dietary intake to birth weight. Am J Clin Nutr , 1743-1749.
Jansson, T., & Powell, T. L. (2013). Role of placental nutrient sensing in developmental programming. Clin Obstet Gynecol , 591-601.
Kappou, D., Vrachnis, N., & Sifakis, S. (2012). Recent Insight into the Role of Insulin-like Growth Factor Axis in Preeclampsia. Dalam S. Sifakis, From Preconception to Postpartum (hal. 147-160). Intech.
Karamizadeh, Z., Saki, S., Kashef, S., & Saki, S. (2008). Comparison of Umbilical Cord and Maternal Serum Levels of IGF-1, Leptin and Cortisol in Appropriate for Gestational Age and Small for Gestational Age Neonates. Int J Endocrinol Metab 2008 Vol 2 , 89-94.
Langford, K. (1998). Maternal and fetal Insulin-Like Growth Factors and Their Binding Proteins in The Second and Third Trimesters of Human Pregnancy. Human Reproduction Vol 13 , 1389-1393.
Latif, L., Brizee, L., Casy, S., Cumble, E., Feucht, S., Glass, R., et al. (2010). Nutritional Interventions for Children with Special Health Care Needs. Washington: Washington State Department of Health.
Laviola, L., Perini, S., Belsanti, G., Natalicchio, A., Montrone, C., Leonardini, A., et al. (2005). Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling. Endocrinology , 1498-1505.
Lawn, J., Cousens, S., & Zupan, J. (2005). 4 million neoatal death: when? where? when? Lancet , 10-18.
Lima, R., Neto, D., Segre, C., & Goldenberg, S. (2004). Insulin-like growth factor-1 and its binding proteins in healthy mothers and their newborns. Einstein , 105-109.
McIntyre, D., Serek, R., Crane, D., Veveris-Lowe, T., Parry, A., Johnson, S., et al. (2000). Placental growth hormone (GH), GH-binding protein; insulin-like growth factor axis in normal, growth retarded, and dibetetic pregnancies: correlation with fetal growth. The Journal of Clinical Endocrinology & Metabolism , 1143-1150.
Montesinos-Correa, H. (2014). Growth and anthropometry: clinical application. Acta Pediatr Mex , 145-151.
Murphy, V., Smith, R., & Clifton, W. G. (2006). Endocrine Regulation of Human Fetal Growth: The Role of The Mother, Placenta and Fetus. Endocrine Review , 141-169.
Nahum, G. (2014). Essensial update: New international standards developed for evaluation of newborn size. Medscape .
Onis, M. d., Ismail, L., Chumlea, C., Onyango, A., Bhutta, Z., Luna, M., et al. (2012). International fetal and newborn growth standards for the 21st century: Anthropometry handbook. University of Oxford.
Pereira-da-Silva, L. (2012). Neonatal Anthropometry: A Tool to Evaluate the Nutritional Status and predict Early and Late Risks. In Handbook of Anthropometry (pp. 1079-1104). SpringerLink.
Pinto, E., Ramos, E., Guamaraes, J., Silva, I., & Barros, H. (2010). Maternal Blood IGFs, cord blood IGFs and lipids, and size at birth: Implication for adult dislypidemia. EuroEpi .
Sferuzzi-Perri, Owens, J., Pringle, K., & Roberts, C. (2011). The neglected role of insulin-like growth factors in the maternal circulation regulating fetal growth. The journal of physiology , 7-20.
Speroff, L., & Fritz, M. A. (2005). Clinical Gynecologic Endocrinology and Infertility. Philadelphia: Lippincott Williams & Wilkins.
Tisi, D., Liu, X., Wykes, L., Skinner, C., & Koski, K. (2005). Insulin-like krowth factor II and binding proteins 1 and 3 from second trimester human amniotic fluid are associated with infant birth weight. American Society for Nutritional Science , 1668-1672.
Wagey, F. W., Joice, K., & Indriani. (2013). IGF-1 Levels Related to Incidence of Macrosomia. Majalah Obstetri dan Ginekologi , 121-124.
Yang, M.-J., Tseng, J.-Y., Chen, C.-Y., & Yeh, C.-C. (2013). Changes in factor-1 during pregnancy and it's relationship to maternal anthropometry. Journal of chinese medical association , 635-639.
Wibowo, T. (2010). Buku Saku Pelayanan Kesehatan Neonatal Esensial. Pedoman Teknis Pelayanan Kesehatan Dasar. Jakarta: Kementerian Kesehatan RI.
World Health Organization). (2008). Measuring a Child Growth. Geneva: World Health Organization.
DOI: https://doi.org/10.26751/jikk.v8i2.294
Refbacks
- There are currently no refbacks.
Universitas Muhammadiyah Kudus
Jl. Ganesha Raya No. 1 Purwosari Kudus 59316
Tel/ Fax +62-291-437218 Email : lppm@umku.ac.id
Jurnal Ilmu Keperawatan dan Kebidanan Indexed by:
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.